研究

研究テーマ研究実績主な研究費取得状況

研究テーマ

• 脳腫瘍および婦人科腫瘍の遺伝子変異検出次世代シークエンサーパネルの構築と運用
  Construction and practical realization of NGS panel sequencing analysis for glioma and gynecologic tumor.
• ＤＮＡメチル化による膵胆管がん予後予測システムの構築
  Construction of prediction system on machine learning for prognosis after surgery and/or its malignancy by DNA methylation analysis.
• 遺伝子改変システムを用いた癌特異的遺伝子変異のフェノタイプ解析
  Phenotype analysis cause by single mutation and/or epigenome alteration using CRISPR-CAS system.
• MSイメージングによるタンパク質発現解析
  Protein expression analysis on MS imaging analysis on tissue.
• デジタル病理システムの構築と運用
  Construction and operation of digital pathology network system

研究実績

2020

• Zaizen Y, Tabata K, Yamano Y, Hebisawa A, Kataoka K, Bychkov A, Johkoh T, Kondoh Y, Fukuoka J. Histology is critical but not always for the diagnosis of chronic hypersensitivity pneumonitis. Respir Investig. 2020 Jul;58(4):285-290.
• Yagi Y, Aly RG, Tabata K, Barlas A, Rekhtman N, Eguchi T, Montecalvo J, Hameed M, Manova-Todorova K, Adusumilli PS, Travis WD. Three-Dimensional Histologic, Immunohistochemical, and Multiplex Immunofluorescence Analyses of Dynamic Vessel Co-Option of Spread Through Air Spaces in Lung Adenocarcinoma. J Thorac Oncol. 2020 Apr;15(4):589-600.
• Hirano T, Shinsato Y, Tanabe K, Higa N, Kamil M, Kawahara K, Yamamoto M, Minami K, Shimokawa M, Arigami T, Yanagita S, Matushita D, Uenosono Y, Ishigami S, Kijima Y, Maemura K, Kitazono I, Tanimoto A, Furukawa T, Natsugoe S. FARP1 boosts CDC42 activity from integrin αvβ5 signaling and correlates with poor prognosis of advanced gastric cancer. Oncogenesis. Feb 6;9(2):13. 2020.
• Kitazono I, Hamada T, Yoshimura T, Kirishima M, Yokoyama S, Akahane T, Tanimoto A. PCP4/PEP19 downregulates neurite outgrowth via transcriptional regulation of Ascl1 and NeuroD1 expression in human neuroblastoma M17 cells. Lab Invest. 2020 Jul 8.
• Akahane T, Kitazono I, Yanazume S, Kamio M, Togami S, Sakamoto I, Nohara S, Yokoyama S, Kobayashi H, Hiraki T, Suzuki S, Ueno S, Tanimoto A. Next-generation sequencing analysis of endometrial screening liquid-based cytology specimens: a comparative study to tissue specimens. BMC Med Genomics. Jul 11;13(1):101. 2020.
• Noguchi H, Kumamoto K, Harada Y, Sato N, Nawata A, Tasaki T, et al. Prevalence of and Helicobacter pylori infection rate in heterotopic gastric mucosa on histological analysis of duodenal specimens from patients with duodenal ulcer. Histol Histopathol. 2020; 35: 169-176.
• Sato N, Tasaki T, Noguchi H, Irie K, Nakayama T. The pathological challenge of establishing a precise diagnosis for pulmonary tumour thrombotic microangiopathy: identification of new diagnostic criteria. Histopathology. 2019; 74: 892-901.
• Hanaka T, Kido T, Noguchi S, Yamada S, Noguchi H, Guo X, Nawata A, Wang KY, Oda K, Takaki T, Izumi H, Ishimoto H, Yatera K, Mukae H. The overexpression of peroxiredoxin-4 affects the progression of idiopathic pulmonary fibrosis. BMC Pulm Med. 2019; 19: 265.
• Guo X, Noguchi H, Ishii N, Homma T, Hamada T, Hiraki T, Zhang J, Matsuo K, Yokoyama S, Ishibashi H, Fukushige T, Kanekura T, Fujii J, Uramoto H, Tanimoto A, Yamada S. The Association of Peroxiredoxin 4 with the initiation and progression of hepatocellular carcinoma. Antioxid Redox Sign. 2019; 30: 1271-1284.
• Yamada, S., Noguchi, H., Tanimoto, A. Critical and diverse in vivo roles of apoptosis signal-regulating kinase 1 in animal models of atherosclerosis and cholestatic liver injury. Histol Histpathol. 2017; 32: 433-444.
• Yokoyama S, Hamada T, Higashi M, Matsuo K, Maemura K, Kurahara H, Horinouchi M, Hiraki T, Sugimoto T, Akahane T, Yonezawa S, Kornmann M, Batra SK, Hollingsworth MA, Tanimoto A. Predicted Prognosis of Patients with Pancreatic Cancer by Machine Learning. Clin Cancer Res. 2020;26(10):2411-21.
• Kawahata T, Kawahara K, Shimokawa M, Sakiyama A, Shiraishi T, Minami K, Yamamoto M, Shinsato Y, Arima K, Hamada H, Furukawa T. Involvement of ribosomal protein L11 expression in sensitivity of gastric cancer against 5 FU. Oncol. Lett.2020; 19: 2258-2264
• Miyake M, Terada T, Shimokawa M, Sugimoto N, Arakawa T, Shimizu K, Igarashi K, Fujita K and Fushinobu S. Structural analysis of β‐L‐arabinobiose‐binding protein in the metabolic pathway of hydroxyproline‐rich glycoproteins in Bifidobacterium longum. The FEBS Journal. 2020
• Kurahara H, Maemura K, Mataki Y, Tanoue K, Iino S, Kawasaki Y, et al. Lung recurrence and its therapeutic strategy in patients with pancreatic cancer. Pancreatology. 2020;20(1):89-94.
• Kijima T, Arigami T, Uenosono Y, Hiraki T, Yanagita S, Matsushita D, Okubo K, Shimonosono M, Ishigami S, Maemura K, Tanimoto A, Natsugoe S. Comparison of HER2 Status Before and After Trastuzumab-based Chemotherapy in Patients With Advanced Gastric Cancer. Anticancer Res. 2020;40(1):75-80.
• Zheng J, Guo X, Shioya A, Yoshioka T, Matsumoto K, Hiraki T, Kusano H, Oyama T, Kurose N, Yamaguchi R, Uramoto H, Ieiri S, Okajima H, Kohno M, Yamada S. Peroxiredoxin 4 promotes embryonal hepatoblastoma cell migration but induces fetal cell differentiation. Am J Transl Res. 2020;12(6):2726-37.
• Higa N, Akahane T, Yokoyama S, Yonezawa H, Uchida H, Takajo T, Kirishima M, Hamada T, Matsuo K, Fujio S, Hanada T, Hosoyama H, Yonenaga M, Sakamoto A, Hiraki T, Tanimoto A, Yoshimoto K. A tailored next-generation sequencing panel identified distinct subtypes of wildtype IDH and TERT promoter glioblastomas. Cancer Sci. 2020 Aug 4.

2019

• Zaizen Y, Kohashi Y, Kuroda K, Tabata K, Kitamura Y, Hebisawa A, Saito Y, Fukuoka J. Concordance between sequential transbronchial lung cryobiopsy and surgical lung biopsy in patients with diffuse interstitial lung disease. Diagn Pathol. 2019 Dec 4;14(1):131.
• Takei R, Yamano Y, Kataoka K, Yokoyama T, Matsuda T, Kimura T, Johkoh T, Tabata K, Fukuoka J, Kondoh Y. Usefulness of new diagnostic criteria for chronic hypersensitivity pneumonitis established on the basis of a Delphi survey: A Japanese cohort study. Respir Investig. 2019 Nov 9. pii: S2212-5345(19)30115-7.
• Hu X, Fujimoto J, Ying L, Fukuoka J, Ashizawa K, Sun W, Reuben A, Chow CW, McGranahan N, Chen R, Hu J, Godoy MC, Tabata K, Kuroda K, Shi L, Li J, Behrens C, Parra ER, Little LD, Gumbs C, Mao X, Song X, Tippen S, Thornton RL, Kadara H, Scheet P, Roarty E, Ostrin EJ, Wang X, Carter BW, Antonoff MB, Zhang J, Vaporciyan AA, Pass H, Swisher SG, Heymach JV, Lee JJ, Wistuba II, Hong WK, Futreal PA, Su D, Zhang J. Multi-region exome sequencing reveals genomic evolution from preneoplasia to lung adenocarcinoma. Nat Commun. 2019 Jul 5;10(1):2978.
• Tabata K, Uraoka N, Benhamida J, Hanna MG, Sirintrapun SJ, Gallas BD, Gong Q, Aly RG, Emoto K, Matsuda KM, Hameed MR, Klimstra DS, Yagi Y. Validation of mitotic cell quantification via microscopy and multiple whole-slide scanners. Diagn Pathol. 2019 Jun 26;14(1):65.
• Enomoto N, Egashira R, Tabata K, Hashisako M, Kitani M, Waseda Y, Ishizuka T, Watanabe S, Kasahara K, Izumi S, Shiraki A, Miyamoto A, Kishi K, Kishaba T, Sugimoto C, Inoue Y, Kataoka K, Kondoh Y, Tsuchiya Y, Baba T, Sugiura H, Tanaka T, Sumikawa H, Suda T. Analysis of systemic lupus erythematosus-related interstitial pneumonia: a retrospective multicentre study. Sci Rep. 2019 May 14;9(1):7355.
• Mori M, Hayashi H, Fukuda M, Honda S, Kitazaki T, Shigematsu K, Matsuyama N, Otsubo M, Nagayasu T, Hashisako M, Tabata K, Uetani M, Ashizawa K. Clinical and computed tomography characteristics of non-small cell lung cancer with ALK gene rearrangement: Comparison with EGFR mutation and ALK/EGFR-negative lung cancer. Thorac Cancer. 2019 Apr;10(4):872-879.
• Akahane T, Yamaguchi T, Kato Y, Yokoyama S, Hamada T, Nishida Y, Higashi M, Nishihara H, Suzuki S, Ueno S, Tanimoto A. Comprehensive validation of liquid-based cytology specimens for next-generation sequencing in cancer genome analysis. PLoS One. 2019 Jun 14;14(6):e0217724.
• Fukukura Y, Kumagae Y, Higashi R, Hakamada H, Takumi K, Maemura K, Higashi M, Kamimura K, Nakajo M, Yoshiura T. Extracellular volume fraction determined by equilibrium contrast-enhanced multidetector computed tomography as a prognostic factor in unresectable pancreatic adenocarcinoma treated with chemotherapy. Eur Radiol. 2019;29(1):353-61.
• Fukukura Y, Kumagae Y, Hirahara M, Hakamada H, Nagano H, Nakajo M, Kamimura K, Nakajo M, Higashi M, Yoshiura T. CT and MRI features of undifferentiated carcinomas with osteoclast-like giant cells of the pancreas: a case series. Abdominal radiology. 2019;44(4):1246-55.
• Kanmura S, Hamamoto H, Tanaka A, Arima S, Sasaki F, Tanoue S, Nasu Y, Hashimoto S, Higashi M, Ido A. Diagnostic utility of linked color imaging in the evaluation of colonic mucosal inflammation in ulcerative colitis: a pilot study. Endosc Int Open. 2019;7(8):E937-E43.
• Kamil M, Shinsato Y, Higa N, Hirano T, Idogawa M, Takajo T, Minami K, Shimokawa M, Yamamoto M, Kawahara K, Yonezawa H, Hirano H, Furukawa F, Yoshimot K, Arita K. High filamin-C expression predicts enhanced invasiveness and　poor outcome in glioblastoma multiforme. Br. J. Cancer., 2019; 120: 819-826
• Higa N, Shinsato Y, Kamil M, Hirano T, Takajo T, Shimokawa M, Minami K, Yamamoto M, Kawahara K, Yonezawa H, Hirano H, Furukawa T,Yoshimoto K, Arita K. Formin-like 1 (FMNL1) Is Associated with Glioblastoma Multiforme Mesenchymal Subtype and Independently Predicts Poor Prognosis. Int. J. Mol. Sci.,2019; 20:6355

2018

• Jing Zhang, Xin Guo, Taiji Hamada, Seiya Yokoyama, Yuka Nakamura, Jianbo Zheng, Nozomu Kurose, Yasuhito Ishigaki, Hidetaka Uramoto, Akihide Tanimoto, Sohsuke Yamada. Protective Effects of Peroxiredoxin 4 (PRDX4) on Cholestatic Liver Injury. Int J Mol Sci. 2018 Aug 24;19(9):2509.
• Honjo K, Hamada T, Yoshimura T, Yokoyama S, Yamada S, Tan YQ, Leung LK, Nakamura N, Ohi Y, Higashi M, Tanimoto A. PCP4/PEP19 upregulates aromatase gene expression via CYP19A1 promoter I.1 in human breast cancer SK-BR-3 cells. Oncotarget. 2018; 9:29619-29633.
• Kanai Y, Nishihara H, Miyagi Y, Tsuruyama T, Taguchi K, Katoh H, Takeuchi T, Gotoh M, Kuramoto J, Arai E, Ojima H, Shibuya A, Yoshida T, Akahane T, Kasajima R, Morita KI, Inazawa J, Sasaki T, Fukayama M, Oda Y. The Japanese Society of Pathology Guidelines on the handling of pathological tissue samples for genomic research: Standard operating procedures based on empirical analyses. Pathol Int. 2018 Feb;68(2):63-90.
• Bandoh N, Akahane T, Goto T, Kono M, Ichikawa H, Sawada T, Yamaguchi T, Nakano H, Kawase Y, Kato Y, Kamada H, Harabuchi Y, Shimizu K, Nishihara H. Targeted next-generation sequencing of cancer-related genes in thyroid carcinoma: A single institution’s experience. Oncol Lett. 2018 Dec;16(6):7278-7286.
• Furukawa T, Tabata S, Yamamoto M, Kawahara K, Shinsato Y, Minami K, Shimokawa M, Akiyama S. Roles of thymidine phosphorylase in cancer biology and anti-cancer therapy. Pharmacol. Res., 2018; 132: 15-20.
• Baba Y, Hayashi S, Nagasato K, Higashi M, Tosuji N, Sonoda S, Yoshiura T. Oxidative stress induced by portal vein embolization in fatty liver: Experimental study of a nonalcoholic steatohepatitis model. Biomedical reports. 2018;9(4):357-63.
• Baba Y, Higashi M, Awai K. A new embolic liquid agent comprised of amino acid. Minimally invasive therapy & allied technologies : MITAT : official journal of the Society for Minimally Invasive Therapy. 2018;27(1):17-21.
• Kumata H, Murakami K, Ishida K, Miyagi S, Arakawa A, Inayama Y, Kinowaki K, Ochiai A, Kojima M, Higashi M, Moritani S, Kuwahara K, Nakatani Y, Kajiura D, Tamura G, Kijima H, Yamakawa M, Shiraishi T, Inadome Y, Murakami K, Suzuki H, Sawai T, Unno M, Kamei T, Sasano H. Steroidogenesis in ovarian-like mesenchymal stroma of hepatic and pancreatic mucinous cystic neoplasms. Hepatology research : the official journal of the Japan Society of Hepatology. 2018;48(12):989-99.

2017

• Nakamura S, Hayashi K, Imaoka Y, Kitamura Y, Akazawa Y, Tabata K, Groen R, Tsuchiya T, Yamasaki N, Nagayasu T, Fukuoka J. Intratumoral heterogeneity of programmed cell death ligand-1 expression is common in lung cancer. PLoS One. 2017 Oct 19;12(10):e0186192.
• Tabata K, Mori I, Sasaki T, Itoh T, Shiraishi T, Yoshimi N, Maeda I, Harada O, Taniyama K, Taniyama D, Watanabe M, Mikami Y, Sato S, Kashima Y, Fujimura S, Fukuoka J. Whole-slide imaging at primary pathological diagnosis: Validation of whole-slide imaging-based primary pathological diagnosis at twelve Japanese academic institutes. Pathol Int. 2017 Nov;67(11):547-554.
• Khalil AA, Sivakumar S, Lucas FAS, McDowell T, Lang W, Tabata K, Fujimoto J, Yatabe Y, Spira A, Scheet P, Nemer G, Kadara H. TBX2 subfamily suppression in lung cancer pathogenesis: a high-potential marker for early detection. Oncotarget. 2017 Aug 4;8(40):68230-68241.
• Ogihara K, Isomoto H, Kurumi H, Kanda T, Hashisako M, Tabata K, Ishii H, Ohnita K, Yamaguchi N, Akazawa Y, Matsushima K, Takeshima F, Kunizaki M, Hidaka S, Nanashima A, Fukuoka J, Nagayasu T, Nakao K. Expression of coproporphyrinogen oxidase is associated with detection of upper gastrointestinal carcinomas by 5-aminolevulinic acid-mediated photodynamic diagnosis. Photodiagnosis Photodyn Ther. 2017 Apr 14. pii: S1572-1000(17)30214-4.
• Yokoyama S, Higashi M, Tsutsumida H, Wakimoto J, Hamada T, Wiest E, Matsuo K, Kitazono I, Goto Y, Guo X, Hamada T, Yamada S, Hiraki T, Yonezawa S, Batra SK, Hollingsworth MA, Tanimoto A: TET1-mediated DNA hypomethylation regulates the expression of MUC4 in lung cancer. Genes Cancer 2017;8:517-27.
• Shimokawa M, Haraguchi T, Minami Y, Yagi F*, Hiemori K, Tateno H, Hirabayashi J. Two carbohydorate recognizing domain from Cycas revolute leaf lectin show the distinct sugar-binding specificity-A unique mannooligosaccharide recognition by N-terminal domain. J. biochem., 2016; 160: 27-35.
• Hiraki T, Yamada S, Higashi M, Hatanaka K, Yokoyama S, Kitazono I, Goto Y, Kirishima M, Batra SK, Yonezawa S, Tanimoto A: Immunohistochemical expression of mucin antigens in gallbladder adenocarcinoma: MUC1-positive and MUC2-negative expression is associated with vessel invasion and shortened survival. Histol Histopathol 2017;32(6):585-1.
• Baba Y, Hayashi S, Nagasato K, Higashi M, Yoshiura T. Preliminary experimental study on splenic hemodynamics of radiofrequency ablation for the spleen. Minimally invasive therapy & allied technologies: MITAT: official journal of the Society for Minimally Invasive Therapy. 2017;26(4):193-9.
• Hashimoto S, Taguchi H, Higashi M, Hatanaka K, Fujita T, Iwaya H, Nakazawa J, Arima S, Iwashita Y, Sasaki F, Nasu Y, Kanmura S, Ido A. Diagnostic efficacy of liquid-based cytology for solid pancreatic lesion samples obtained with endoscopic ultrasound-guided fine-needle aspiration: Propensity score-matched analysis. Dig Endosc. 2017 Jul;29(5):608-616.
• Matsuda A, Higashi M, Nakagawa T, Yokoyama S, Kuno A, Yonezawa S, Narimatsu H. Assessment of tumor characteristics based on glycoform analysis of membrane-tethered MUC1. Lab Invest. 2017 Sep;97(9):1103-1113.
• Mizuno K, Mataki H, Arai T, Okato A, Kamikawaji K, Kumamoto T, Hiraki T, Hatanaka K, Inoue H, Seki N: The microRNA expression signature of small cell lung cancer: tumor supressors of miR-27a-5p and miR-34b-3p and their targeted oncogenes. J Hum Genet 2017;62(7):671-8.
• Honjo K, Hiraki T, Higashi M, Noguchi H, Nomoto M, Yoshimura T, Batra SK, Yonezawa S, Semba I, Nakamura N, Tanimoto A, Yamada S. Immunohistochemical expression profiles of mucin antigens in salivary gland mucoepidermoid carcinoma: MUC4- and MUC6-negative expression predicts a shortened survival in the early postoperative phase. Histol Histopathol 2017;33(2):201-13.

2016

• Nunomura S, Tanaka T, Nakayama T, Otani K, Ishii H, Tabata K, Kondoh Y, Kataoka K, Johkoh T, Taniguchi H, Fukuoka J. Pulmonary alveolar proteinosis-like change: A fairly common reaction associated with the severity of idiopathic pulmonary fibrosis. Respir Investig. 2016 Jul;54(4):272-9.
• Yokoyama S, Higashi M, Kitamoto S, Oeldorf M, Knippschild U, Kornmann M, Maemura K, Kurahara H, Wiest E, Hamada T, Kitazono I, Goto Y, Tasaki T, Hiraki T, Hatanaka K, Mataki Y, Taguchi H, Hashimoto S, Batra SK, Tanimoto A, Yonezawa S, Hollingsworth MA. Aberrant methylation of MUC1 and MUC4 promoters are potential prognostic biomarkers for pancreatic ductal adenocarcinomas.Oncotarget. 2016 Jul 5;7(27):42553-42565.
• Nakajo M, Nakajo M, Nakayama H, Jinguji M, Nakabeppu Y, Higashi M, et al. Dexamethasone Suppression FDG PET/CT for Differentiating between True- and False-Positive Pulmonary and Mediastinal Lymph Node Metastases in Non-Small Cell Lung Cancer: A Pilot Study of FDG PET/CT after Oral Administration of Dexamethasone. Radiology. 2016;279(1):246-53.
• Yamada Y, Yamamoto H, Kohashi K, Ishii T, Iura K, Maekawa A, Bekki H, Otsuka H, Yamashita K, Tanaka H, Hiraki T, Mukai M, Shirakawa A, Shinnou Y, Jinno M, Taguchi K, Maehara Y, Iwamoto Y, Oda Y: Histological Spectrum of Angiofibroma of Soft Tissue: Histological and genetic analysis of 13 cases. Histopathology 2016;39(6):894-901.
• Yoshimura T, Hamada T, Hijioka H, Souda M, Hatanaka K, Yoshioka T, Yamada S, Tsutsui M, Umekita Y, Nakamura N, Tanimoto A. PCP4/PEP19 promotes migration, invasion and adhesion in human breast cancer MCF-7 and T47D cells. Oncotarget. 2016 Aug 2;7(31):49065-49074.

2015

• Shimokawa M., Kitahara K., Fujita K. Characterization of a β-L-arabinopyranosidase from Bifidobacterium longum subsp. longum. J. Appl. Glycosci., 2015; 62: 1-6.
• B Bohara M, Hirabaru M, Fujio S, Higashi M, Yonezawa H, Karki P, Hanaya R, Hirano H, Tokimura H, Arita K. Choroid Plexus Tumors: Experience of 10 Cases with Special References to Adult Cases. Neurologia medico-chirurgica. 2015;55(12):891-900.
• Fukukura Y, Shindo T, Higashi M, Takumi K, Umanodan T, Yoneyama T, Yoshiura T. Computed tomography and magnetic resonance imaging features of lipid-rich neuroendocrine tumors of the pancreas. World journal of gastroenterology: WJG. 2015;21(34):10008-17.
• Hassani S, Castillo A, Ohori J, Higashi M, Kurono Y, Akiba S, Koriyama C. Molecular Pathogenesis of Human Papillomavirus Type 16 in Tonsillar Squamous Cell Carcinoma. Anticancer research. 2015;35(12):6633-8.
• Hashimoto S, Fukukura Y, Koriyama C, Mataki Y, Maemura K, Shinchi H, Jain M, Batra SK, Yonezawa S. Higashi M, Yokoyama S, Yamamoto T, Goto Y, Kitazono I, Hiraki T, et al. Mucin expression in endoscopic ultrasound-guided fine-needle aspiration specimens is a useful prognostic factor in pancreatic ductal adenocarcinoma. Pancreas. 2015;44(5):728-34.
• Takumi K, Fukukura Y, Higashi M, Ideue J, Umanodan T, Hakamada H, Kanetsuki I, Yoshiura T. Pancreatic neuroendocrine tumors: Correlation between the contrast-enhanced computed tomography features and the pathological tumor grade. Eur J Radiol. 2015;84(8):1436-43.
• Higashi M, Yokoyama S, Yamamoto T, Goto Y, Kitazono I, Hiraki T, Taguchi H, Hashimoto S, Fukukura Y, Koriyama C, Mataki Y, Maemura K, Shinchi H, Jain M, Batra SK, Yonezawa S: Mucin (MUC) expression in EUS-FNA specimens is a useful prognostic factor in pancreatic ductal adenocarcinoma. Pancreas 2015;44:728-34.

主な研究費取得状況

谷本昭英

東美智代

田崎貴嗣

横山勢也

濱田大治

下川倫子