研究

研究テーマ研究実績主な研究費取得状況

研究テーマ

• 脳腫瘍および婦人科腫瘍の遺伝子変異検出次世代シークエンサーパネルの構築と運用
  Construction and practical realization of NGS panel sequencing analysis for glioma and gynecologic tumor.
• ＤＮＡメチル化による膵胆管がん予後予測システムの構築
  Construction of prediction system on machine learning for prognosis after surgery and/or its malignancy by DNA methylation analysis.
• 遺伝子改変システムを用いた癌特異的遺伝子変異のフェノタイプ解析
  Phenotype analysis cause by single mutation and/or epigenome alteration using CRISPR-CAS system.
• MSイメージングによるタンパク質発現解析
  Protein expression analysis on MS imaging analysis on tissue.
• デジタル病理システムの構築と運用
  Construction and operation of digital pathology network system

主な研究費取得状況

谷本昭英

東美智代

北園育美

田崎貴嗣

横山勢也

濱田大治

霧島茉莉

野口紘嗣

研究実績

2025

• Kitazono I, Murakami M, Takeda A, Noguchi H, Tasaki T, Kirishima M, Higashi M, Ueda K, Tanimoto A. Pulmonary pleomorphic carcinoma: a rare case showing arterial carcinomatosis mimicking pulmonary artery intimal sarcoma. Pathol Int. 2025 Feb;75(2):114‑120. doi:10.1111/pin.13508. Epub 2025 Jan 9.
• Noumi M, Higashi M, Kitazono I, Yokoyama S, Tasaki T, Noguchi H, et al. Expression of mucins MUC1 and MUC4 in curative resected gallbladder adenocarcinoma. Histology & Histopathology. 2025;18928. doi:10.14670/HH‑18‑928
• Kimura S, Noguchi H, Sato H, Shimajiri S, Nakayama T. High histamine expression by early‑stage squamous cell carcinoma of the tongue is associated with a poor prognosis. Histology & Histopathology. 2025 May 14:18938. doi:10.14670/HH‑18‑938. Online ahead of print
• Margeta D, Noguchi H, Khazaie S, Herlitz LC, Augustine JJ, Heeger PS, Tambur AR, Fairchild RL, Baldwin WM 3rd. Spatial transcriptomics of Glomerulo‑centric antibody mediated rejection in renal transplants. Clinical Immunology. 2025 May;274:110460. doi:10.1016/j.clim.2025.110460. Epub 2025 Feb 22.
• Jojima K, Minato A, Noguchi H, Tsuda Y, Fujimoto N. Clinical Outcomes of Micropapillary Urothelial Carcinoma of the Bladder Treated With Radical Cystectomy. Cancer Diagnosis and Prognosis. 2025 Jan 3;5(1):122‑126.
• Hamada T, Yokoyama S, Akahane T, Matsuo K, Kitazono I, Furukawa T, Tanimoto A. Electroporation Induces Unexpected Alterations in Gene Expression: A Tip for Selection of Optimal Transfection Method. Current Issues in Molecular Biology. 2025 Jan 31;47(2):91. doi:10.3390/cimb47020091.
• Kamiimabeppu D, Baba K, Wada M, Kuroshima N, Kawasaki Y, Sasaki K, Arigami T, Kitazono I, Ohtsuka T. Surgical management for acute ischemic colitis associated with decompression sickness. Surg Case Rep. 2025;11(1):24‑0185. doi:10.70352/scrj.cr.24‑0185. Epub 2025 Apr 10.
• Yanazume S, Kobayashi Y, Kirita Y, Kitazono I, Nagata C, Kozai A, Tanimoto A, Kobayashi H. A potential inflammatory biomarker for advanced endometrial cancer treated with lenvatinib plus pembrolizumab. J Obstet Gynaecol Res. 2025 Jan;51(1):e16182. doi:10.1111/jog.16182.
• Suzuki S, Akahane T, Tanimoto A, Higashi M, Kitazono I, Kirishima M, Nishigaki M, Ikeda T, Kanemitsu S, Nakazawa J, Akahane E, Nishihara H, Uozumi K, Yoshimitsu M, Ishitsuka K, Ueno S I. Comparison of actionable alterations in cancers with kinase fusion, mutation, and copy number alteration. PLoS One. 2025 Jan 23;20(1):e0305025. doi:10.1371/journal.pone.0305025.
• 田崎 貴嗣, 馬場 直子, 野口 紘嗣, 村上 未樹, 北薗 育美, 東 美智代, 谷本 昭英. 典型的な皮膚病変を呈したMpoxの1症例. 診断病理 42: 146-149, 2025

2024

• Kirishima M, Yokoyama S, Akahane T, Higa N, Uchida H, Yonezawa H, Matsuo K, Yamamoto J, Yoshimoto K, Hanaya R, Tanimoto A. Prognosis prediction via histological evaluation of cellular heterogeneity in glioblastoma. Scientific Reports. 2024 Oct 23;14(1):24955. doi:10.1038/s41598‑024‑76826‑8. PMID: 39438642
• Kitazono I, Akahane T, Yokoyama S, Kubota E, Nishida‑Kirita Y, Noguchi H, Murakami M, Yanazume S, Kobayashi H, Tanimoto A. Cervical cytology preserves histologically detected surface epithelial slackening, unique to the POLE mutation‑subtype in endometrial cancer. In Vivo. 2024 Jan–Feb;38(1):321‑333. doi:10.21873/invivo.13442.
• Yoshimura T, Hirano Y, Hamada T, Yokoyama S, Suzuki H, Takayama H, Migita H, Ishida T, Nakamura Y, Ohsawa M, Asakawa A, Ishihata K, Tanimoto A. Exercise suppresses head and neck squamous cell carcinoma growth via Oncostatin M. Cancers (Basel). 2024 Mar 18;16(6):1187. doi:10.3390/cancers16061187.
• Hidaka Y, Tanoue S, Ayukawa T, Takumi K, Noguchi H, Higashi M, Idichi T, Kawasaki Y, Kurahara H, Mataki Y, Ohtsuka T, Koriyama C. Impact of pancreatic ductal occlusion on postoperative outcomes in pancreatic head cancer patients undergoing neoadjuvant therapy. J Gastroenterol. 2024 Sep;59(9):858‑868. doi:10.1007/s00535‑024‑02125‑8. Epub 2024
• Yanazume S, Kirita Y, Kobayashi Y, Kitazono I, Akahane T, Nagata C, Kozai A, Tanimoto A, Kobayashi H. Can endometrial cytology identify patients who would benefit from immunotherapy? Acta Cytologica. 2024;68(2):128‑136. doi:10.1159/000538288. Epub 2024 Mar 12.
• Ejima F, Fukukura Y, Kamimura K, Nakajo M, Ayukawa T, Kanzaki F, Yanazume S, Kobayashi H, Kitazono I, Imai H, Feiweier T, Yoshiura T. Oscillating Gradient Diffusion‑Weighted MRI for risk stratification of uterine endometrial cancer. J Magn Reson Imaging. 2024 Jul;60(1):67‑77. doi:10.1002/jmri.29106.
• Kitazono I, Akahane T, Sasaki H, Ohi Y, Shinden Y, Takajo T, Tasaki T, Higashi M, Noguchi H, Hisaoka M, Tanimoto A. Malignant phyllodes tumor with EGFR variant III mutation: a rare case report with immunohistochemical and genomic studies. Pathol Res Pract. 2024 Jul;259:155389. doi:10.1016/j.prp.2024.155389. Epub 2024 Jun 2.
• Furuzono N, Togami S, Kitazono I, Nishikawa T, Tanimoto A, Kobayashi H. Malignant peripheral nerve sheath tumor of the cervix in an adolescent with neurofibromatosis type 1: a case report and review of literature. J Obstet Gynaecol Res. 2024 Dec;50(12):2372‑2376. doi:10.1111/jog.16139. Epub 2024 Nov 5.
• Seiya Yokoyama, Kei Matsuo, Akihide Tanimoto. Mucins. Methylation-Specific Electrophoresis. Springer US. 2024 Feb. doi: 10.1007/978-1-0716-3670-1_22
• 寺原 航, 田崎 貴嗣, 霧島 茉莉, 北薗 育美, 村上 未樹, 田畑 和宏, 東 美智代, 野元 祐輔, 白濱 浩, 谷本 昭英. 第2期梅毒疹の2症例. 診断病理 41: 281-285, 2024.
• 寺原 航, 田崎 貴嗣, 霧島 茉莉, 北薗 育美, 村上 未樹, 田畑 和宏, 東 美智代, 谷本 昭英. Low grade non-intestinal-type sinonasal adenocarcinomaの1例. 診断病理. 41:  255-259. 2024

2023

• Higashi Y, Nakamura K, Takaoka R, Tani M, Noma Y, Mori K, Yamashiro K, Yokoyama S, Hamada T, Sugiura T*.
  Identification of neck lymph node metastasis‑specific microRNA—implication for use in monitoring or prediction of neck lymph node metastasis. Cancers. 2023;15(15):3769. doi:10.3390/cancers15153769
• Tasaki T, Shiba E, Noguchi H, Kirishima M, Kitazono I, Terabaru W, Tabata K, Higashi M, Shinohara N, Sasaki H, Nakajo M, Nakajo M, Hisaoka M, Tanimoto A*.
  Low‑grade fibromyxoid sarcoma with massive degeneration: a case of unusual gross and histological features. In Vivo. 2023;37:2863‑2868.
• Hamada T, Higashi M, Yokoyama S, Akahane T, Hisaoka M, Noguchi H, Furukawa T, Tanimoto A.
  MALAT1 functions as a transcriptional promoter of the MALAT1::GLI1 fusion for truncated GLI1 protein expression in cancer. BMC Cancer. 2023 May 10;23(1):424. doi:10.1186/s12885‑023‑10867‑6.
• Yoshino H, Yokoyama S, Tamai M, Okamura S, Iizasa S, Sakaguchi T, Osako Y, Inoguchi S, Matsushita R, Yamada Y, Nakagawa M, Tatarano S, Tanimoto A, Enokida H*.
  Characterization and treatment of gemcitabine‑ and cisplatin‑resistant bladder cancer cells with a pan‑RAS inhibitor. FEBS Open Bio. 2023;13(6):e13616. doi:10.1002/2211‑5463.13616
• Kimura S, Sato H, Shimajiri S, Umehara T, Noguchi H, Niino D, Nakayama T.
  Association of troponin I and macrophages in cardiac tamponade with Stanford type A aortic dissection. Heliyon. 2023 Oct 9;9(10):e20791. doi:10.1016/j.heliyon.2023.e20791. eCollection 2023 Oct
• Higa N, Akahane T, Yokoyama S, Makino R, Yonezawa H, Uchida H, Takajo T, Kirishima M, Hamada T, Noguchi N, Otsuji R, Kuga D, Nagasaka S, Yamahata H, Yamamoto J, Yoshimoto K, Tanimoto A, Hanaya R.
  Favorable prognostic impact of phosphatase and tensin homolog alterations in wild‑type isocitrate dehydrogenase and telomerase reverse transcriptase promoter glioblastoma. Neuro‑Oncology Advances. 2023 Jun 28;5(1):vdad078. doi:10.1093/noajnl/vdad078
• Makino R, Higa N, Akahane T, Yonezawa H, Uchida H, Takajo T, Fujio S, Kirishima M, Hamada T, Yamahata H, Kamimura K, Yoshiura T, Yoshimoto K, Tanimoto A, Hanaya R.
  Alterations in EGFR and PDGFRA are associated with the localization of contrast‑enhancing lesions in glioblastoma. Neuro‑Oncology Advances. 2023 Sep 2;5(1):vdad110. doi:10.1093/noajnl/vdad110
• Minato A, Kudo Y, Noguchi H, Kohi S, Hasegawa Y, Sato N, Hirata K, Fujimoto N.
  Receptor for hyaluronic acid‑mediated motility (RHAMM) is associated with prostate cancer migration and poor prognosis. Cancer Genomics Proteomics. 2023 Mar‑Apr;20(2):203‑210. doi:10.21873/cgp.20375
• Iwaya H, Tanimoto A, Toyodome K, Kojima I, Hinokuchi M, Tanoue S, Hashimoto S, Kawahira M, Arima S, Kanmura S, Akahane T, Higashi M, Suzuki S, Ueno S, Ohtsuka T, Ido A.
  Next‑generation sequencing analysis of pancreatic cancer using residual liquid cytology specimens from endoscopic ultrasound‑guided fine‑needle biopsy: a prospective comparative study with tissue specimens. Diagnostics (Basel). 2023;13(6).
• Higa N, Akahane T, Hamada T, Yonezawa H, Uchida H, Makino R, Watanabe S, Takajo T, Yokoyama S, Kirishima M, Matsuo K, Fujio S, Hanaya R, Tanimoto A, Yoshimoto K.
  Distribution and favorable prognostic implication of genomic EGFR alterations in IDH‑wildtype glioblastoma. Cancer Med. 2023 Jan;12(1):49‑60. doi:10.1002/cam4.4939
• Yanazume S, Iwakiri K, Kobayashi Y, Kitazono I, Akahane T, Mizuno M, Togami S, Tanimoto A, Kobayashi H.
  Cytopathological features associated with POLE mutation in endometrial cancer. Cytopathology. 2023 May;34(3):211‑218. doi:10.1111/cyt.13215. Epub 2023 Feb 28
• Kitazono I, Akahane T, Yokoyama S, Kobayashi Y, Togami S, Yanazume S, Tasaki T, Noguchi H, Tabata K, Kobayashi H, Tanimoto A.
  “Surface epithelial slackening” pattern in endometrioid carcinoma: a morphological feature for differentiating the POLE mutation‑subtype from the no specific molecular profile subtype. Pathol Res Pract. 2023 Jul;247:154563. doi:10.1016/j.prp.2023.154563. Epub 2023 May 19
• Kawaji K, Nakajo M, Shinden Y, Jinguji M, Tani A, Hirahara D, Kitazono I, Ohtsuka T, Yoshiura T.
  Application of machine learning analyses using clinical and [^18F]*‑FDG‑PET/CT radiomic characteristics to predict recurrence in patients with breast cancer. Mol Imaging Biol. 2023 Oct;25(5):923‑934. doi:10.1007/s11307‑023‑01823‑8. Epub 2023 May 16
• Yumisashi R, Saito R, Togami S, Kobayashi Y, Kitazono I, Tanimoto A, Kobayashi H.
  Molecular biological analysis revealed a case of synchronous endometrial and ovarian cancer with different histological grade as metastatic ovarian cancer from endometrial cancer: case report and review of literature. J Obstet Gynaecol Res. 2023 Nov;49(11):2766‑2770. doi:10.1111/jog.15773. Epub 2023 Aug 21
• 田崎 貴嗣, 霧島 茉莉, 北薗 育美, 田畑 和宏, 東 美智代, 安村 拓人, 豊川 建二, 谷本 昭英. 胸部大動脈瘤を呈した巨細胞性動脈炎の1例. 診断病理 40:　91-95, 2023.

2022

• Higashi M, Hamada T, Sasaki K, Tsuruda Y, Shimonosono M, Kitazono I, Kirishima M, Tasaki T, Noguchi H, Tabata K, Hisaoka M, Fukukura Y, Ohtsuka T, Tanimoto A.
  Esophageal plexiform fibromyxoma: a case report with molecular analysis for MALAT1‑GLI1 fusion. Pathol Res Pract. 2022;233:153878. doi:10.1016/j.prp.2022.153878
• Hamada T, Akahane T, Yokoyama S, Higa N, Kirishima M, Matsuo K, Shimokawa M, Yoshimoto K, Tanimoto A.
  An oncogenic splice variant of PDGFRα in adult glioblastoma as a therapeutic target for selective CDK4/6 inhibitors. Sci Rep. 2022 Jan 24;12(1):1275. doi:10.1038/s41598‑022‑05391‑9
• Kirishima M, Akahane T, Higa N, Suzuki S, Ueno S, Yonezawa H, Uchida H, Hanaya R, Yoshimoto K, Shimajiri S, Kitazono I, Tanimoto A.
  IDH‑mutant astrocytoma with an evolutionary progression to CDKN2A/B homozygous deletion and NTRK fusion during recurrence: a case report. Pathol Res Pract. 2022 Nov;239:154163. doi:10.1016/j.prp.2022.154163. Epub 2022 Oct 15
• Kirishima M, Yokoyama S, Matsuo K, Hamada T, Shimokawa M, Akahane T, Sugimoto T, Tsurumaru H, Ishibashi M, Mataki Y, Ootsuka T, Nomoto M, Hayashi C, Horiguchi A, Higashi M, Tanimoto A.
  Gallbladder microbiota composition is associated with pancreaticobiliary and gallbladder cancer prognosis. BMC Microbiol. 2022 May 27;22(1):147. doi:10.1186/s12866‑022‑02557‑3
• Kitazono I, Akahane T, Kobayashi Y, Yanazume S, Tabata K, Tasaki T, Noguchi H, Kirishima M, Higashi M, Kobayashi H, Tanimoto A.
  Pelvic carcinosarcoma showing diverse histology and hierarchical gene mutation with a common POLE mutation to endometrial endometrioid carcinoma: a case report. Int J Surg Pathol. 2022 Dec;30(8):891‑899. doi:10.1177/10668969221088880. Epub 2022 Mar 31
• Yano E, Nakajo M, Jinguji M, Tani A, Kitazono I, Yoshiura T.
  I-131 false‑positive uptake in a thymic cyst with expression of the sodium‑iodide symporter: a case report. Medicine (Baltimore). 2022 Jul 1;101(26):e29282. doi:10.1097/MD.0000000000029282. PMCID: PMC9239621
• Sakae H, Mawatari S, Oda K, Tabu K, Kumagai K, Mizuno K, Nozuma S, Kitazono I, Kanmura S, Ido A.
  A case of autoimmune hepatitis with thymoma and myasthenia gravis. Clin J Gastroenterol. 2022 Aug;15(4):765‑770. doi:10.1007/s12328‑022‑01641‑5. Epub 2022 Jun 27
• Hozaka Y, Oi H, Satake S, Uchino Y, Goto Y, Idichi T, Tanoue K, Yamasaki Y, Kawasaki Y, Mataki Y, Kurahara H, Nakaji A, Higashi M, Tanimoto A, Sugiura T, Ohtsuka T.
  Are intratumoral microbiota involved in the progression of intraductal papillary mucinous neoplasms of the pancreas? Surgery. 2022
• Kudo Y, Sato N, Oba T, Adachi Y, Amaike T, Koga A, Kohi S, Noguchi H, Nakayama T, Hirata K.
  Concurrent overexpression of two hyaluronidases, KIAA1199 and TMEM2, strongly predicts shorter survival after resection in pancreatic ductal adenocarcinoma. Pancreas. 2022 Aug 1;51(7):800‑807. doi:10.1097/MPA.0000000000002106
• Tanigawa M, Koga Y, Naito Y, Yamaguchi H, Iwasaki T, Kohashi K, Ohike N, Hanada K, Higashi M, Komatsu M, Imai H, Yamakita K, Nagakawa T, Okabe Y, Kato S, Noguchi H, Nakayama T, Yasuda M, Kusano H, Akiba J, Oda Y, Yano H.
  Pancreatic hamartoma: detection of harbouring NAB2::STAT6 fusion gene. Histopathology. 2022 Sep;81(3):319‑328. doi:10.1111/his.14703. Epub 2022 Jul 14
• Kimura S, Noguchi H, Yoshida K, Sato H, Nanbu U, Niino D, Shimajiri S, Nakayama T.
  Relationship of histamine expression with chemokine balance in the tumor microenvironment of squamous cell carcinoma of the tongue. Head Neck. 2022 Jul;44(7):1554‑1562. doi:10.1002/hed.27056. Epub 2022 Apr 11
• Yokoyama S, Iwaya H, Akahane T, Hamada T, Higashi M, Hashimoto S, Tanoue S, Ohtsuka T, Ido A, Tanimoto A.
  Sequential evaluation of MUC promoter methylation using next‑generation sequencing‑based custom‑made panels in liquid‑based cytology specimens of pancreatic cancer. Diagn Cytopathol. 2022 Nov;50(11):499‑507. doi:10.1002/dc.25022
• Hamada T, Yokoyama S, Akahane T, Matsuo K, Tanimoto A.
  Genome editing using Cas9 ribonucleoprotein is effective for introducing PDGFRA variant in cultured human glioblastoma cell lines. Int J Mol Sci. 2022 Dec 28;24(1):500. doi:10.3390/ijms24010500
• Khedraki R, Noguchi H, Baldwin W M 3rd.
  Balancing the view of C1q in transplantation: consideration of the beneficial and detrimental aspects. Front Immunol. 2022 Mar 24;13:873479. doi:10.3389/fimmu.2022.873479. Epub 2022
• Kitazono I, Kobayashi Y, Akahane T, Yamaguchi T, Yanazume S, Nohara S, Sakamoto I, Tabata K, Tasaki T, Kobayashi H, Tanimoto A.
  ATM immunohistochemistry as a potential marker for differential diagnosis of no specific molecular profile subtype and POLE‑mutation subtype endometrioid carcinoma. Pathol Res Pract. 2022 Feb;230:153743. doi:10.1016/j.prp.2021.153743. Epub 2021 Dec 18
• Orita Y, Kamio M, Tokudome A, Kitazono I, Ichihara F, Kobayashi H.
  Successful management of vulvar proximal‑type epithelioid sarcoma in pregnancy. Gynecol Oncol Rep. 2022 Jan 21;39:100933. doi:10.1016/j.gore.2022.100933. PMCID:PMC8789591
• Togami S, Ushiwaka T, Kitazono I, Yanazume S, Kamio M, Tanimoto A, Kobayashi H.
  One‑step nucleic acid amplification (OSNA) assay for detecting lymph node metastasis in cervical and endometrial cancer: a preliminary study. J Gynecol Oncol. 2022 Mar;33(2):e11. doi:10.3802/jgo.2022.33.e11. Epub 2021 Nov 15. PMCID:PMC8899876
• Higa N, Akahane T, Yokoyama S, Yonezawa H, Uchida H, Takajo T, Makino R, Watanabe S, Kirishima M, Tanimoto A, Yoshimoto K, Hanaya R.
  Prognostic impact of PDGFRA gain/amplification and MGMT promoter methylation status in patients with IDH wild‑type glioblastoma. Neuro‑Oncology Advances. 2022 Jun 21;4(1):vdac097. doi:10.1093/noajnl/vdac097
• Iwaizako H, Nishikawa T, Kitazono I, Tanimoto A, Okamoto Y.
  Unknown primary malignant small round cell tumor masquerading as acute leukemia. Pediatr Int. 2022 Jan;64(1):e15158. doi:10.1111/ped.15158
• Minato A, Noguchi H, Kimuro R, Mirii H, Noma Y, Hasegawa Y, Tomisaki I, Harada K, Fujimoto N.
  Prognostic value of squamous differentiation in upper tract urothelial carcinoma treated with radical nephroureterectomy. Anticancer Res. 2022 Jan;42(1):263‑269. doi:10.21873/anticanres.15481

2015-2021

• 研究実績 2015年-2021年はこちら